2010May 044

Dr Helen Cassaday

MA (Oxon), PhD (Lond), CPsychol AFBPsS

 

 

 

 

Research

My group investigate the underlying biology of associative learning processes, fundamental to normal cognition, in laboratory rats and mice. The animal learning theories can also be applied to our understanding of age-related cognitive decline, as well as to human diseases in which associative processes are disordered.

When there is a time gap between events, we are less able to make a connection between them in learning and later memory. Thus it is harder to keep track of things that could in fact be causally related, in order - for example - to know that even distant engine noise can predict a future hazard or to anticipate dinner based on the smell of raw ingredients. The ability successfully to bridge a time gap between events is known to deteriorate with age in humans and other animals. This line of work (funded by the BBSRC) aims to identify the neural substrates of trace conditioning, and to compare these with those of delay-dependent forgetting measured in other procedures.

In schizophrenia, we find that learning occurs inappropriately, about stimuli that would normally be treated as irrelevant, redundant or in some other way indistinct. This line of work (funded by the MRC and Wellcome Trust) has focused on the neural substrates of selective learning. Recent work compared the effects of localised treatments within nucleus accumbens on latent inhibition, based on past experience with the cue or ‘acquired salience’, and cue competition through overshadowing, based on relative intensity of the cue or ‘intrinsic salience’.

To promote translation of these findings to our understanding of human disorder, a number of my graduate students (Ellen Migo, Ebrahim Kantini, Zhimin He, Meghan Thurston, Becci Gould) have also successfully established associative learning procedures suitable for use with human participants.

In addition to projects on selective learning mechanisms and their dysfunction, we have shown the validity of a non-invasive objective measure of stress in laboratory mice (Ann Fitchett, BBSRC-funded studentship, welfare remit).

If you have achieved (or are expecting) a good degree in psychology, neuroscience or a related discipline and want to find a PhD project related to one of these areas of interest, you are very welcome to contact me. I can also provide further information on the various PhD funding opportunities here at Nottingham  - mailto:helen.cassaday@nottingham.ac.uk (or phone + 44(0) 115 951 5124).

 

Publications

Copyright note

Some of the documents listed below are available for downloading. These documents have been provided as a means to ensure timely dissemination of scholarly and technical work on a noncommercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that the works have been made available electronically. It is understood that all persons will adhere to the terms and constraints invoked by each author's copyright. These works may not be re-posted without the explicit permission of the copyright holder.

Peer reviewed journal articles

Cassaday, H.J., Hodges, H. & Gray, J.A. (1991). The effects of pharmacological and neurotoxic manipulation of serotonergic activity on latent inhibition in the rat: implications for the neural basis of acute schizophrenia. Serotonin-Related Psychiatric Syndromes: Clinical and Therapeutic Links (International Congress and Symposium Series), 165, 99-105. pdf schizophrenia; latent inhibition; 5-hydroxytryptamine; 5-MeO-DMT; rat

Cassaday, H.J., Hodges, H. & Gray, J.A. (1993). The effects of ritanserin, RU 24969 and 8-OH-DPAT on latent inhibition in the rat. Journal of Psychopharmacology, 7, 63-71. pdf 5-hydroxytryptamine; ritanserin; RU 24969; 8-hydroxy-2-(di-n-propylamino)tetralin; latent inhibition; rat

Cassaday, H.J., Mitchell, S.N., Williams, J.H. & Gray, J.A. (1993). 5,7-Dihydroxytryptamine lesions in the fornix-fimbria attenuate latent inhibition. Behavioral and Neural Biology, 59, 194-207. [Published erratum appears in Behavioral and Neural Biology, 60, p. 186.] pdf schizophrenia; latent inhibition; 5-hydroxytryptamine; 5,7-dihydroxytryptamine; rat

Rawlins, J.N.P., Lyford, G., Seferiades, A., Deacon, R.M.J. & Cassaday, H.J. (1993). Critical determinants of non-spatial working memory deficits in rats with conventional lesions of hippocampus or fornix. Behavioral Neuroscience, 107, 420-433. pdf hippocampus; fornix; working memory; nonspatial; matching-to-sample; rat

Rawlins, J.N.P., Deacon, R.M.J., Yee, B.K. & Cassaday, H.J. (1994). Does it still make sense to develop a declarative memory theory of hippocampal function? Behavioral and Brain Sciences, 17, 492-493. pdf hippocampus; declarative memory; relational learning; configural learning; nonspatial theory; rat

Cassaday, H.J. & Rawlins, J.N.P. (1995). Fornix-fimbria section and working memory deficits in rat: Stimulus complexity and stimulus size. Behavioral Neuroscience, 109, 594-606. pdf fornix; hippocampus; working memory; nonspatial; matching-to-sample; rat

Tai, C.-T., Cassaday, H.J., Feldon, J. & Rawlins, J.N.P. (1995). Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats. Neurobiology of Learning and Memory, 64, 36-48. pdf schizophrenia; latent inhibition; nucleus accumbens; NMDA; mesolimbic dopamine system

Gray, J.A., Joseph, M.H., Hemsley, D.R., Young, A.M.J., Warburton, E.C., Boulenguez, P., Grigoryan, G.A., Peters, S.L., Rawlins, J.N.P., Tai, C.-T., Yee, B.K., Cassaday, H., Weiner, I., Gal, G., Gusak, O., Joel, D., Shadrach, E., Shalev, U., Tarrasch, R. & Feldon, J. (1995). The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behavioural Brain Research, 71, 19-31. pdf schizophrenia; latent inhibition; nucleus accumbens; hippocampal formation; mesolimbic dopamine system

Cassaday, H.J. & Gaffan, E.A. (1996). A novel test of visual learning in the rat: Effects of 8-OH-DPAT and WAY-100579. Journal of Psychopharmacology, 10, 195-205. pdf visual learning; rat; 5-hydroxytryptamine; 8-OH-DPAT; WAY-100579; Alzheimer’s disease

Cassaday, H.J. & Rawlins, J.N.P. (1997). The hippocampus, objects and their contexts. Behavioral Neuroscience, 111, 1228-1244. pdf hippocampus; working memory; nonspatial; matching-to-sample; contextual cues; rat

Carter, S.J. & Cassaday, H.J. (1998). State-dependent retrieval and chlorpheniramine. Human Psychopharmacology, 13, 513-523. pdf antihistamine; human memory; retrieval; context; state-dependency

Ferguson, E. & Cassaday, H.J. (1999). The Gulf War and illness by association. British Journal of Psychology, 90, 459-475. pdf Gulf War; Pavlovian conditioning; conditioned sickness; interleukin-1; organophosphates; environmental stressors

Cassaday, H.J., Simpson, E.L. & Gaffan, E.A. (2000). Rapid visual learning in the rat: Effects at the 5HT1a receptor subtype. Quarterly Journal of Experimental Psychology, 53B, 225-238. pdf visual learning; rat; 5-hydroxytryptamine; 8-OH-DPAT; WAY-100635; Alzheimer’s disease

Parker, A., Ngu, H. & Cassaday, H.J. (2001). Odour and Proustian memory: Reduction of context-dependent forgetting and multiple forms of memory. Applied Cognitive Psychology, 15, 159-171. pdf context-dependent memory; state dependency; odour cues; free recall; problem solving; spatial learning

Cassaday, H.J., Shilliam, C.S. & Marsden, C.A. (2001). Serotonergic depletion  increases conditioned suppression to background stimuli in the rat. Journal of Psychopharmacology, 15, 83-92. pdf trace conditioning; contextual conditioning; 5,7-dihydroxytryptamine; serotonin depletion; rat

Ferguson, E. & Cassaday, H.J. (2001/2002). Theoretical accounts of Gulf War Syndrome: From environmental toxins to psychoneuroimmunology and neurodegeneration. Behavioural Neurology, 13, 133-147. pdf cytokines; interleukin-1; stress; Gulf War; Pavlovian conditioning; neurodegeneration

Cassaday, H.J., Bloomfield, R.E. & Hayward, N. (2002). Relaxed conditions can provide memory cues, in both undergraduates and primary school children. British Journal of Educational Psychology, 72, 531-547. pdf context-dependent memory; state dependency; odour cues; free recall; cued recall; problem solving

Cassaday, H.J., Norman, C., Shilliam, C.S., Vincent, C. and Marsden, C.A. (2003). Intra-ventricular 5,7 dihydroxytryptamine lesions disrupt acquisition of working memory task rules but not later working memory performance. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 27, 147-156. pdf learning; rat; serotonin depletion; 5,7-dihydroxytryptamine; working memory

Norman, C. & Cassaday, H.J. (2003). Amphetamine increases aversive conditioning to diffuse contextual stimuli and to a discrete trace stimulus when conditioned at higher footshock intensity. Journal of Psychopharmacology, 17, 67-76. pdf  amphetamine; contextual conditioning; dopamine; trace conditioning

Nayak, S. & Cassaday, H.J. (2003). The novel dopamine D4 receptor agonist (PD 168,077 maleate): doses with different effects on locomotor activity are without effect in classical conditionining. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 27, 441-449. pdf conditioning; dopamine D4 agonist; locomotor activity; PD 168,077; rat

Hall, C.A., Cassaday, H.J. & Derrington, A.M. (2003). The effect of stimulus height on visual discrimination in horses. Journal of Animal Science, 81, 1715-1720. pdf discrimination; height; horses; learning; stimuli; vision

Ferguson, E., Cassaday, H.J., Erskind, J. & Delahaye, G. (2004). Individual differences in the temporal variability in medically unexplained symptom reporting. British Journal of Health Psychology,9, 219-240. pdf medically unexplained symptoms; Big 5 personality domains; multivariate linear modelling; Gulf War; Pavlovian conditioning; sickness response

Ferguson, E., Cassaday, H.J. & Bibby, P. (2004). Odors and sounds as triggers for medically unexplained symptoms: A fixed occasion diary study of in Gulf War veterans. Annals of Behavioral Medicine, 27, 205-214. pdf medically unexplained symptoms; odour cues; Gulf War; Pavlovian conditioning; sickness response

Norman, C. & Cassaday, H.J. (2004). Disruption of latent inhibition to a contextual stimulus with systemic amphetamine. Neurobiology of Learning and Memory, 82, 61-64. pdf latent inhibition; amphetamine; contextual conditioning; rat

Norman, C. & Cassaday, H.J. (2004). CER to discrete and contextual stimuli:  Effects of stimulus modality depend on strain of rat. Physiology & Behavior, 82, 611-619. pdf strain differences; CER; Dark Agouti; Wistar; stimulus modality; discrete and contextual conditioning

Kantini, E., Norman C. & Cassaday H.J. (2004). Amphetamine decreases the expression and acquisition of appetitive conditioning but increases the acquisition of anticipatory responding over a trace interval. Journal of Psychopharmacology, 18, 516-526. pdf amphetamine; appetitive conditioning; dopamine; trace conditioning

Cassaday, H.J., Nelson, A.J.D. & Norman C. (2005). Haloperidol can increase responding to both discrete and contextual cues in trace conditioned rats. Behavioural Brain Research, 158, 31-42. pdf haloperidol; trace conditioning; contextual conditioning; animal models; schizophrenia

Cassaday, H.J., Horsley, R.R. & Norman C. (2005). Electrolytic lesions to nucleus accumbens core and shell have dissociable effects on conditioning to discrete and contextual cues in aversive and appetitive procedures respectively. Behavioural Brain Research, 160, 222-235. pdf trace conditioning; contextual conditioning; nucleus accumbens; dopamine

Fitchett, A.E., Collins, S.A., Mason, H., Barnard, C.J. & Cassaday, H.J. (2005). Urinary corticosterone measures: Effects of strain and social rank in BKW and CD-1 mice. Behavioural Processes, 70, 168-176. pdf BKW; CD-1; corticosterone; mouse; social rank; strain difference

Fitchett, A.E., Collins, S.A., Barnard, C.J. & Cassaday, H.J. (2005). Subordinate male mice show long-lasting differences in spatial learning that persist when housed alone. Neurobiology of Learning & Memory, 84, 247-251. pdf CD-1 mouse; social rank; spatial learning; corticosterone

Migo, E.M., Corbett, K., Graham, J., Smith, S., Tate, S., Moran, P.M.& Cassaday, H.J. (2006). A novel test of conditioned inhibition correlates with personality measures of schizotypy and reward sensitivity. Behavioural Brain Research, 168, 299-306. pdf associative learning; conditioned inhibition; visual learning; schizotypy; BIS/BAS

Hall, C.A. & Cassaday, H.J. (2006). An investigation into the effect of floor colour on the behaviour of the horse. Applied Animal Behaviour Science. 99, 301-314. pdf horse; colour aversion; flooring; vision

Fitchett, A.E., Barnard, C.J. & Cassaday, H.J. (2006). There's no place like home: Cage odours and place preference in subordinate CD-1 male mice. Physiology & Behavior. 87, 955-962. pdf CD-1 mouse; social rank; conditioned place preference; odour cues

Hall, C.A, Cassaday, H.J., Vincent C.J & Derrington A.M. (2006). Cone excitation ratios correlate with color discrimination performance in the horse. Journal of Comparative Psychology, 120, 438-448. pdf horse; color vision; cone excitation ratios; discrimination learning

Horsley, R.R., Norman, C. & Cassaday, H.J. (2007). Lesions of the nucleus accumbens shell can reduce activity in the elevated plus-maze. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 906-914. pdf anxiety; dopamine; electrolytic; elevated plus maze; lesion; locomotion; nucleus accumbens; rat

Horsley, R.R. & Cassaday, H.J. (2007). Methylphenidate can reduce selectivity in associative learning in an aversive trace conditioning task. Journal of Psychopharmacology, 21, 492-500. pdf aversive conditioning; trace interval; contextual conditioning; rat; methylphenidate; dopamine

Barklamb, K. & Cassaday, H.J. (2007). Rated salience of internal and external cues in cases of self-reported hunger and illness. Appetite, 49, 511-519. pdf salience; internal cues; external cues; hunger; illness

Horsley, R.R., Moran, P.M. & Cassaday, H.J. (2008). Appetitive overshadowing is disrupted by systemic amphetamine but not by electrolytic lesions to the nucleus accumbens shell. Journal of Psychopharmacology, 22, 172-181. [Uncorrected proofs published, corrected online June 2008.] pdf appetitive conditioning; overshadowing; amphetamine; nucleus accumbens; dopamine; rat

Horsley, R.R.  & Cassaday, H.J. (2008). Amphetamine effects in appetitive acquisition depend on the modality of the stimulus rather than its relative validity. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32, 1057-1063. pdf amphetamine; appetitive conditioning; dopamine; partial reinforcement; rat

Grimond-Billa, S.K., Norman, C., Bennett, G.W. & Cassaday, H.J. (2008). Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect. Journal of Psychopharmacology, 22, 290-299. pdf aversive conditioning; trace conditioning; neurotensin; PD 149163; SR 142948A; rat

Cassaday, H.J., Finger, B.C. & Horsley, R.R. (2008). Methylphenidate and nicotine focus responding to an informative discrete CS over successive sessions of appetitive conditioning. Journal of Psychopharmacology, 22, 849-859. pdf methylphenidate; nicotine; trace interval; appetitive conditioning; rat

Slack, M.D., Hewitt, K.N., Ebling, F.J.P. & Cassaday, H.J. (2009). Sex differences in emotionality in C3H/HeH mice, with hypogonadal mutant to distinguish activational effects of gonadal hormones. Physiology & Behavior, 96, 30-36. pdf behaviour; sex differences; C3H/HeH mouse; hypogonadal

Fitchett, A.E., Barnard, C.J. & Cassaday, H.J. (2009). Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice. Animal Welfare, 18, 21-31. pdf animal welfare; CD-1 mouse; social housing; social rank; T-maze alternation; urinary corticosterone

Norman, C., Grimond-Billa, S.K., Bennett, G.W. & Cassaday, H.J. (2010). A neurotensin agonist and antagonist decrease and increase activity, respectively, but do not preclude discrete cue conditioning. Journal of Psychopharmacology, 24, 373-381. pdf appetitive conditioning; neurotensin; PD149163; rat; SR142948A; trace conditioning

Nelson, A.J.D., Thur, K.E., Marsden, C.A., & Cassaday, H.J. (2010). Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition. Neuroscience, 170, 99-106. pdf latent inhibition; prelimbic cortex; infralimbic cortex; dopamine; schizophrenia

Nelson, A.J.D., Thur, K.E., Marsden, C.A. & Cassaday H.J. (2010). Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place. Behavioral Neuroscience, 124, 789-799. pdf nucleus accumbens; dopamine; rat; object memory; place memory

Nelson, A.J.D., Thur, K.E., Horsley, R.R., Spicer, C., Marsden, C.A. & Cassaday, H.J. (2011). Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition. Pharmacology, Biochemistry and Behavior, 98, 1-7. pdf latent inhibition; nucleus accumbens; core; shell; dopamine

Kantini, E., Cassaday, H.J., Hollis, C.P. & Jackson, G.M (2011). The normal inhibition of associations is impaired by clonidine in Tourette Syndrome. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20, 96-106. pdf Tourette syndrome; associative learning; conditioned inhibition; clonidine

Nelson, A.J.D., Cooper, M.T., Thur, K.E., Marsden, C.A. & Cassaday, H.J. (2011). The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location and objects, Behavioral Neuroscience, 125, 396-403. pdf object recognition memory; prelimbic; infralimbic; dopamine

Nelson, A.J.D., Thur, K.E., Spicer, C., Marsden, C.A. & Cassaday, H.J. (2011). Catecholaminergic depletion in nucleus accumbens enhances trace conditioning, Advances in Medical Sciences, 56, 71-79. pdf conditioned emotional response; associative learning; 6-hydroxydopamine

Kantini, E., Cassaday, H.J., Batty, M.J., Hollis, C. & Jackson, G.M. (2011). Associative learning in ADHD: improved expression under methylphenidate. Open Journal of Psychiatry, 1, 20-29. pdf ADHD; associative learning; conditioned inhibition; methylphenidate

Nelson, A.J.D., Thur, K.E., Marsden, C.A. & Cassaday, H.J. (2011). Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing. Journal of Psychopharmacology, 25, 1649-1660. pdf dopamine; latent inhibition; nucleus accumbens; overshadowing

He, Z., Cassaday, H.J., Howard, R.C., Khalifa, N. & Bonardi, C.M. (2011). Impaired Pavlovian conditioned inhibition in offenders with personality disorders. Quarterly Journal of Experimental Psychology, 64, 2334-2351. pdf associative learning; conditioned inhibition; personality disorders; forensic

Nelson, A.J.D., Thur, K.E., Marsden, C.A. & Cassaday, H.J. (2012). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. International Journal of Neuropsychopharmacology, 15, 485-496. pdf core; latent inhibition; nucleus accumbens; serotonin; shell

Olarte Sanchez, C.M., Valencia Torres L., Body, S., Cassaday, H.J., Bradshaw, C.M., Szabadi, E. & Goudie, A.J. (2012). A clozapine-like effect of cyproheptadine on progressive ratio schedule performance. Journal of Psychopharmacology, 26, 857-870. pdf progressive ratio schedule; cyproheptadine; atypical antipsychotics; clozapine; haloperidol; chlordiazepoxide; Δ9‑tetrahydrocannabinol; reinforcer efficacy; rats

Olarte Sanchez, C.M., Valencia Torres L., Body, S., Cassaday, H.J., Bradshaw, C.M. & Szabadi, E. (2012). Effect of orexin-B-saporin induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule. Journal of Psychopharmacology, 26, 871-886. pdf orexins; orexin-saporin; operant behaviour; incentive value; motor performance; progressive ratio schedule

He, Z., Cassaday, H.J., Park, S.B.G. & Bonardi, C. (2012). When to hold that thought: An experimental study showing reduced inhibition of pre-trained associations in schizophrenia. PLoS ONE, 7, e42175. pdf

Nelson, A.J.D., Thur, K.E. & Cassaday, H.J. (2012). Dopamine D1 receptor involvement in latent inhibition and overshadowing. International Journal of Neuropsychopharmacology, 15, 1513-1523. pdf D1 receptor; latent inhibition; overshadowing; SCH 23390; SKF 81297

Nelson, A.J.D., Thur, K.E., Marsden, C.A. & Cassaday, H.J. (2013). Paradoxical effects of low dose MDMA on latent inhibition in the rat. Neuropharmacology, 67, 331-336. pdf MDMA; 5-hydroxytryptamine; latent inhibition; HPLC-ED

He, Z., Cassaday, H.J., Bonardi, C. & Bibby, P.A. (2013).  Do personality traits predict individual differences in excitatory and inhibitory learning? Frontiers in Psychology (Personality Science and Individual Differences), 4, Article 245. pdf conditioned inhibition; behavioural activation; behavioural inhibition; neuroticism

Ferguson, E., Ward, J.W., Skatova, A., Cassaday, H.J., Bibby, P.A. & Lawrence, C. (2013). Health specific traits beyond the Five Factor Model, cognitive processes and trait expression: Replies to Watson (2012), Matthews (2012) and Haslam, Jetten, Reynolds and Reicher (2012). Health Psychology Review, 7 (1, supplement), S85-S103. pdf personality; health; factor analysis; determinism; empathy

Olarte-Sánchez, C.M., Valencia-Torres, L., Cassaday, H.J., Bradshaw C.M. & Szabadi, E. (2013). Effects of SKF-83566 and haloperidol on performance on progressive-ratio schedules maintained by sucrose and corn oil reinforcement: Quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR). Psychopharmacology, 230, 617-630. pdf progressive ratio schedule; mathematical principles of reinforcement; mathematical model; D1- and D2-like receptors; SKF-83566; haloperidol; incentive value; sucrose; corn oil; rats

 

Contributions to books

Cassaday, H.J. (1997). Latent inhibition: relevance to the neural substrates of schizophrenia and schizotypy? In: G. Claridge (Ed.) Schizotypy: Implications for Illness and Health. Oxford University Press. pp.124-144.

Cassaday, H.J. & Norman, C. (2002). Mediating from memory to attention: necessity of the accumbens connection? In: A. Parker, E. Wilding and T. Bussey (Eds.) The Cognitive Neuroscience of Memory: Encoding and Retrieval. Psychology Press.

Hall, C.A., Cassaday, H.J., Vincent, C.J. & Derrington, A.M. (2006). The selection of coloured stimuli by the horse (Equus caballus). In: A. Hemmings, P. Harris, M. Moore-Colyer, S. Tracey & A. Northrop (Eds.) Applying Equine Science: Research into Business. Nottingham University Press.

Cassaday, H.J. & Moran, P.M. (2010). Latent inhibition and other salience modulation effects: same neural substrates? In: R.E. Lubow & I. Weiner (Eds.) Latent Inhibition: Cognition, Neuroscience, Applications and Schizophrenia.  Cambridge University Press. pdf

Cassaday, H.J. (2010). Blocking, Overshadowing and Related Concepts. In: I. Stolerman (Ed.) Encyclopedia of Psychopharmacology. Springer-Verlag. pdf

Nelson, A.J.D., Kantini, E & Cassaday, H.J. (2011). An associative analysis of Tourette Syndrome. In: Haselgrove M. & Hogarth L. (Eds.) Clinical Applications of Learning Theory. Psychology Press. pdf

 

Conference abstracts (2000-)

Norman, C. & Cassaday, H.J. (2000). Amphetamine affects conditioning but not breadth of attention to weak predictors. Journal of Psychopharmacology, 14 (3, supplement).

Nayak, S. & Cassaday, H.J. (2000) Effect of a novel D4 agonist (PD168077 maleate) in a trace conditioning procedure in the rat. Journal of Psychopharmacology, 14 (3, supplement).

Norman, C., Nayak, S. & Cassaday, H.J. (2001). Effects of NMDA lesions to the nucleus accumbens on conditioning to weak predictors in a trace conditioning procedure. Journal of Psychopharmacology, 15 (3, supplement).

Kantini, E. & Cassaday, H.J. (2002). Effects of d-amphetamine on classical conditioning in an appetitive trace conditioning procedure. Journal of Psychopharmacology, 16 (3, supplement).

Horsley R. & Cassaday, H.J. (2002). Correlational and salience overshadowing in the rat. Journal of Psychopharmacology, 16 (3, supplement).

Norman, C. & Cassaday, H.J.  (2002). Strain differences in conditioning to discrete and contextual stimuli in a trace conditioning procedure in the rat. Journal of Psychopharmacology, 16 (3, supplement).

Horsley, R. & Cassaday, H.J. (2003). Preliminary experiment finds no effect of 1mg/kg of d-amphetamine on overshadowing in the rat. Journal of Psychopharmacology, 17 (3, supplement).

Norman, C., Cassaday, H.J. (2003). Amphetamine disruption of latent inhibition to context.Journal of Psychopharmacology, 17 (3, supplement).

Grimond, S.K., Norman, C., Bennett, G.W. & Cassaday H.J. (2004). Effects of a neurotensin agonist (PD 149163) on associative learning in a trace conditioning procedure. Journal of Psychopharmacology, 18 (3, supplement).

Horsley, R., Norman, C. & Cassaday, H.J. (2004). Electrolytic lesions of the shell (but not core) sub-territory of the nucleus accumbens potentiate contextual conditioning in trace conditioned rats. Journal of Psychopharmacology, 18 (3, supplement).

Horsley, R.R., Norman, C. & Cassaday, H.J. (2005). Shell lesions of the nucleus accumbens reduce activity on the elevated plus maze. Journal of Psychopharmacology, 19 (3, supplement).

Hall, C.A, Cassaday, H.J., Vincent C.J & Derrington A.M. (2005). Behavioral and physiological measures of dichromatic color vision in the horse (Equus caballus). Proceedings of Measuring Behaviour (Wageningen, 30 August-2 September 2005, pp 591-592).

Hall, C.A., Cassaday, H.J., Vincent, C.J. & Derrington, A.M. (2006). The selection of coloured stimuli by the horse (Equus caballus). In: L. Clarke, P. Harris, S Tracey, M. Moore-Colyer & A. Hemmings (Eds.) Applying Equine Science: Research into Business. (2nd BSAS Equine Conference, Royal Agricultural College, Cirencester, 20-21 September 2005, pp 217-221).

Grimond, S.K., Moklas, M.M., Spicer, C., Cassaday, H.J., & Bennett, G.W. (2006).  Effect of central acute administration of the neurotensin agonist: PD149163 on scopolamine-induced deficits of recognition memory using two novel object discrimination (NOD) protocols. FENS Forum Abstracts, vol.3, 020.18.

Horsley, R.R., & Cassaday, H.J. (2006). Methylphenidate reduces selectivity in aversive and appetitive trace conditioning procedures. Journal of Psychopharmacology, 20 (5, supplement).

Horsley, R.R., Finger, B., & Cassaday, H.J. (2007). Nicotine dose dependently focuses responding over successive sessions of appetitive conditioning. Journal of Psychopharmacology, 21 (7, supplement).

Norman, C., Grimmond-Billa, S.K., Bennett, G.W., Cassaday, H.J. (2007) Effects of a neurotensin agonist (PD149163) and antagonist (SR142948A) on conditioning in an appetitive trace conditioning procedure, Journal of Psychopharmacology, 21 (7, supplement).

Nelson, A.J.D., Thur, K.E., Spicer, C., Marsden, C.A. & Cassaday, H.J. (2009). 6-hydroxdopamine lesions of the nucleus accumbens core enhance trace conditioning. Behavioural Pharmacology, 20(S1), 94.

Kantini, E., Batty, M.J., Hollis, C.P., Jackson, G.M. & Cassaday, H.J. (2009). Pavlovian conditioning in Tourette Syndrome and ADHD: Conditioned inhibition reduced by medication in Tourette’s. Behavioural Pharmacology, 20(S1), 94.

Nelson, A.J.D., Thur, K.E., Spicer, C., Marsden, C.A. & Cassaday, H.J. (2009). 6- hydroxdopamine lesions to the shell, not core, of the nucleus accumbens produce abnormally persistent latent inhibition with weak preexposure. Behavioural Pharmacology, 20(S1), 93.

Nelson, A.J.D., Thur, K.E., Dudley, J., Marsden, C.A. & Cassaday, H.J. (2009). The effect of dopamine depletion within the core and medial shell of the nucleus accumbens on memory for objects and place. Behavioural Pharmacology, 20(S1), 23.

Cassaday, H.J., Thur, K.E., Marsden, C.A., & Nelson, A.J.D. (2010). 6-hydroxydopamine lesions to the nucleus accumbens shell and core, comparison with the effects of amphetamine on latent inhibition and overshadowing. FENS Forum Abstracts, vol.5, 057.14.

Nelson, A.J.D., Thur, K.E., Marsden, C.A., & Cassaday, H.J. (2010). Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition. FENS Forum Abstracts, vol.5, 057.60.

Cassaday, H.J., Nelson, A.J.D., Thur, K.E., Horsley, R.R., Spicer, C., Marsden, C.A. (2010). Enhanced latent inhibition after haloperidol microinjection in shell, but not core, of the nucleus accumbens: Comparison with the effects of 6-hydroxydopamine. Journal of Psychopharmacology, 24 (3, supplement). 

Olarte Sanchez, C.M., Valencia Torres, L., Body, S., Cassaday, H.J., Bradshaw, C.M., Szabadi, E. (2010). Effect of destruction of lateral hypothalamic orexinergic neurones on progressive ratio schedule performance: Evidence for an effect on motor performance. Journal of Psychopharmacology, 24 (3, supplement). 

Nelson, A.J.D., Thur, K.E., Marsden, C.A., Cassaday, H.J. (2010). Dissociable effects of catecholaminergic depletion within the prelimbic and infralimbic cortices on recognition memory for objects, place and temporal order. Journal of Psychopharmacology, 24 (3, supplement). 

Thur, K.E., Nelson, A.J.D., Cooper, M.T., Marsden, C.A., Cassaday, H.J. (2010). Differential effects of pre- and infra-limbic dopamine depletion on trace conditioning measured in a CER procedure. Journal of Psychopharmacology, 24 (3, supplement). 

Cassaday, H.J., Fitchett, A.E. (2011). How social housing affects learning in mice. Annals of Warsaw University of Life Sciences – SGGW: Animal Science, 48, 51-57.

Cassaday, H.J., Thur, K.E., Marsden, C.A., Nelson A.J.D. (2011). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. Annals of Warsaw University of Life Sciences – SGGW: Animal Science, 48, 92-93.

Cassaday, H.J., Thur, K.E., Marsden, C.A., Nelson A.J.D. (2011). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. Frontiers in Behavioral Neuroscience, EBBS abstract D11-65, p 144.

Thur, K.E., Marsden, C.A., Nelson, A.J.D., Cassaday H.J. (2011). Acute treatment with MDMA enhanced latent inhibition produced with few pre-exposures. Frontiers in Behavioral Neuroscience, EBBS abstract D11-95, p 149.

Olarte Sanchez, C.M., Valencia Torres, L., Body, S., Cassaday, H.J., Bradshaw, C.M., Szabadi, E. (2011). Effect of orexin-B-saporin induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule. Frontiers in Behavioral Neuroscience, EBBS abstract D12-97, p 206.

Olarte Sanchez, C.M., Valencia-Torres, L., Body, S., Cassaday, H.J., Bradshaw, C.M., Szabadi, E. (2012). Effect of an orexin-1 receptor antagonist on progressive ratio schedule performance: Evidence for an involvement of orexin-1 receptors in the regulation of incentive value. Journal of Psychopharmacology, 26 (8, supplement).

 

Research awards

Internal

University of Nottingham School of Psychology Departmental Research Grant (for equipment): £5K; 1996.

University of Nottingham New Lecturers Award (for equipment): £12K; 1996.

University of Nottingham School of Psychology Pump Priming Grant: Effects of social status in mice on learning (to support Biotechnology and Biological Sciences Research Council PhD student); £3K; 2002.

University of Nottingham School of Psychology Pump Priming Grant: Neurotensin and learning (to support Institute of Neuroscience PhD student); £3K; 2003.

University of Nottingham School of Psychology Pump Priming Grant: How does testosterone deficiency affect cognitive function and emotionality? (to support MPhil student); £3K; 2005.

Medical Research Council Doctoral Training Account Studentship: joint with Chris Bradshaw; 2008-2011.

Economic & Social Research Council Doctoral Training Centre Studentship: joint with Claire Lawrence; 2011-2015.


External

Medical Research Council: Serotonin and selection for learning: Effects of systemic drug administration and neurotoxic lesions in the rat; £38K; sole applicant; 1997-1998.

The Wellcome Trust: Selectivity in associative learning: Effects of amphetamine and lesions to the nucleus accumbens in the rat; £128K; sole applicant; 1999-2002.

The Wellcome Trust (extension): Selectivity in associative learning; £24K; sole applicant; 2002-2003.

Health & Safety Executive: Identifying associative triggers for non-specific symptomatology in the workplace; £225K; joint with Eamonn Ferguson, School of Psychology; 2001-2005 (extended).

Biotechnology and Biological Sciences Research Council Committee Studentship: Effects of housing on glucocorticoids and cognition in mice; £35K; joint with Sarah Collins and Chris Barnard, School of Biology; 2002-2005.

The Wellcome Trust: The neuropharmacological substrates of stimulus associability in the rat; £374K; PI with CIs Paula Moran, School of Psychology, Simon Beckett and Charles Marsden, School of Biomedical Sciences; 2008-2011.

The Wellcome Trust: The role of dopamine receptor subtypes in selection of information for learning; £220K; CI with PI Paula Moran, School of Psychology, other CIs Kevin Fone, School of Biomedical Sciences and John Waddington, Royal College of Surgeons in Ireland; 2008-2011.

The Wellcome Trust: Biomedical Vacation Scholarship to support summer intern; 2009.

British Association of Psychopharmacology: BAP Education: In Vivo Training Initiative to support summer intern; 2009.

The Wellcome Trust: Biomedical Vacation Scholarship to support summer intern; 2010.

Biotechnology and Biological Sciences Research Council Committee: Keeping track of things: Forming associations between temporally separated events; £522K (fEC); PI with CI Kevin Fone, School of Biomedical Sciences, and Researcher CI Marie Pezze; 2013-2016.

 

Posts and education

BA, MA (Hons): Experimental Psychology, Upper Second Class; University College, University of Oxford  (1986, 1990)

PhD: Psychopharmacology (SERC-funded studentship); Institute of Psychiatry, University of London (1990)

MRC funded post doc: Department of Experimental Psychology, University of Oxford (3/1/90 - 31/12/92)

Wellcome Trust funded post doc: Department of Experimental Psychology, University of Oxford (1/1/93 - 31/12/95)

Lecturer: School of Psychology, University of Nottingham (1/1/96-31/7/03)

Senior Lecturer/Associate Professor: School of Psychology, University of Nottingham (1/8/03-31/7/06)

Reader in Behavioural Neuroscience: School of Psychology, University of Nottingham (from 1/8/06)

 

Current graduate students

Rebecca Gould (year 1 PhD: ESRC DTC Studentship)

 

Completed graduate students

Christine Norman, School of Psychology Studentship (PhD, 2002)

Ebrahim Kantini (MPhil, 2004)

Ellen Migo (MSc, 2004)

Carol Wyldes (née Hall; PhD, 2005)

Rachel Horsley, School of Psychology Studentship (PhD, 2006)

Ann Fitchett, BBSRC Committee Studentship (PhD, 2007)

Sophie Grimond-Billa, Institute of Neuroscience Studentship (PhD, 2007)

Meghan Slack (MPhil, 2007)

Melissa Moyer (MSc, 2008)

Ebrahim Kantini, ORS scholarship (PhD, 2010)

Nagat  Salem Aburabia, funded by Libyan government (PhD, 2010)

Zhimin He, School of Psychology Studentship (PhD, 2011)

Meghan Thurston (née Slack), School of Psychology Studentship (PhD, 2011)

Cristian Olarte-Sanchez, MRC DTA Studentship (PhD, 2012)

Rebecca Gould (MSc, 2012)

 

Current undergraduate teaching

1st year Addiction and the Brain

2nd year Neuroscience and Behaviour

I also contribute guest lectures to 1st year Biological Psychology and 2nd year Practical Methods in Cognitive Neuroscience

 

External examining

Undergraduate: Field of Psychology, Department of Human Sciences, Buckinghamshire Chilterns, University College (2000-2003)

Taught postgraduate: MSc in Cognitive Neuroscience, Durham University (2008-2010)

MSc(Res): Durham University (2006)

PhDs: University of London (2000 & 2002); University of Leicester (2001); University of Oxford (2005 & 2011); University of Reading (2007); University of Bristol (2012); Newcastle University (2012)

 

Societies and committees

British Association for Psychopharmacology: Full member

British Psychological Society: Chartered Member and Associate Fellow

British Neuroscience Association: Full member

European Brain and Behaviour Society: Ordinary member

Experimental Psychology Society: Ordinary member

Research Defence Society /Understanding Animal Research

 

Experimental Psychology Society: Committee member (1999-2002)

Standing Advisory Committee for the Welfare of Animals in Psychology (2001-2009)

Biotechnology and Biological Sciences Research Council (BBSRC): Training Awards Committee (2008-2011)

BBSRC: Animal Sciences Committee (Winter Meeting 2009, ad hoc)

Experimental Psychology Society: Honorary Secretary Elect (2010)

Experimental Psychology Society: Honorary Secretary (2011-present)

Joint Committee for Psychology in Higher Education (2011-present)

British Psychological Society: Research Board and Ethics Committee, as Responsibility Holder for Animal Welfare in Psychology (2013-present)

 

Contact information

Dr Helen Cassaday

School of Psychology
University of Nottingham
University Park
Nottingham NG7 2RD

Room number: B32

Student drop in times (without appointment): Mondays 9.30-10.30 am; Tuesdays 3-4 pm 

EPS administration: EPS-enquiries@nottingham.ac.uk

 

My e-mail: helen.cassaday@nottingham.ac.uk

 

Tel:   + 44 (0) 115 951 5124 (direct line)

          + 44 (0) 115 84 68578 (EPS administration)

          + 44 (0) 115 951 5361 (alternative for undergraduate and postgraduate enquiries)

Fax:  +44 (0) 115 951 5324

2010May 044

 




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HTML: Lee Melton


School of Psychology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Tel: +44 [0]115-951-5361, Fax: +44 [0]115-951-5324